SphingoTec’s innovative biomarkers to enable personalized medicine in septic organ failure
• Sepsis is a life-threatening medical emergency that quickly escalates into multiple organ failure.
• SphingoTec’s biomarkers for assessing organ function in real-time help guide clinical decision making by providing patient-specific information.
• Multiple presentations at the Weimar Sepsis Update in Weimar help push forward the science and practice of precision medicine with diagnosis and biomarker-guided therapy.
Hennigsdorf/Berlin, Germany, September 9, 2021 –
Diagnostics company SphingoTec GmbH (“SphingoTec”) announces a series of presentations demonstrating the utility of its innovative biomarkers in sepsis, positively impacting diagnostic and treatment decisions for critically ill patients. The new data will be presented at the 10th Weimar Sepsis Update, Germany.
In the oral presentation on the “Properties of Proenkephalin in septic acute kidney injury”, Dr. med. Christian Nusshag presented the results of a prospective observational study and the performance of kidney function biomarker Proenkephalin (penKid). Measured on top of standard of care, penKid can reliably indicate changes in renal function more dynamically than serum creatinine and can also provide additional diagnostic information on renal function, even when the patient is under renal replacement therapy.
In addition to the research presentation, during a lunch symposium, new data will highlight the utility of the biomarkers in clinical routine as well as in biomarker-guided clinical trials in sepsis. In the presentation “Implementing new Biomarkers in Daily Practice: Proenkephalin and bioactive Adrenomedullin in sepsis”, Dr. med. Lukas Martin from the Uniklinik RWTH Aachen, shares the insights from the first hospital to have implemented the innovative biomarkers in clinical routine. The regular measurements of the biomarkers penKid and bio-ADM have supported clinicians to improve diagnosis, help earlier risk stratification and optimize the treatment of critically ill patients. Bioactive adrenomedullin (bio-ADM) is a dynamic biomarker delivering real-time information on the endothelial function, one of the most common causes of septic shock. Moreover, increased bio-ADM levels were used as inclusion criteria in the AdrenOSS-2 Phase II trial to identify patients with endothelial dysfunction. In the presentation “Biomarker-guided Approach for the Treatment of Septic Shock – Precision Medicine in the AdrenOSS-2”, Prof. Dr. med. Tobias Schürholz from the Uniklinik RWTH Aachen will show a closer look at the steps taken to achieve precision medicine in septic organ failure.
Dr. Andreas Bergmann, CEO and founder of SphingoTec said “it is clear that sepsis is not only characterized by a high incidence worldwide, but it is also diagnostically underserved. Our biomarkers provide actionable information on pathophysiological mechanisms in sepsis. By early identifying and monitoring the hallmarks of sepsis, such as endothelial dysfunction and kidney dysfunction, our biomarkers can provide patient-specific information, paving the way for personalized medicine in sepsis, and beyond.”
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10th Weimar Sepsis Update
Oral presentation
• Properties of Proenkephalin in septic acute kidney injury. Speaker: Dr. Med. Christian Nusshag, University Hospital Heidelberg.
Session: WS2: European Group on Immunology of Sepsis (EGIS)
Lunch symposium: Precision Medicine in Septic Organ Failure
• Implementing new Biomarkers in Daily Practice: Proenkephalin and bioactive Adrenomedullin in sepsis. Speaker: Priv. Doz. Dr. Med. Lukas Martin, Uniklinik RWTH Aachen
• Biomarker-guided Approach for the Treatment of Septic Shock – Precision Medicine in the AdrenOSS-2. Speaker: Prof. Dr. Med. Tobias Schürholz, Uniklinik RWTH Aachen
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About SphingoTec
SphingoTec GmbH ("SphingoTec"; Hennigsdorf near Berlin, Germany) develops and markets innovative in vitro diagnostic (IVD) tests for novel and proprietary biomarkers for the diagnosis, prediction and monitoring of acute medical conditions. SphingoTec's proprietary biomarker portfolio includes bioactive Adrenomedullin (bio-ADM), a unique biomarker for real-time assessment of endothelial function in conditions like sepsis or congestive heart failure, Proenkephalin (penKid), a unique biomarker for real-time assessment of kidney function, and Dipeptidyl Peptidase 3 (DPP3), a unique biomarker for cardiac depression. IVD tests for SphingoTec’s proprietary biomarkers are made available as sphingotest® microtiter plate tests as well as point-of-care tests on the Nexus IB10 immunoassay platform. SphingoTec’s subsidiary Nexus Dx Inc. (San Diego, CA, USA) produces the tests alongside a broad menu of established and commonly used tests for acute and critical care.
Ruxandra Lenz
Sr. Manager Marketing and Communications
SphingoTec GmbH
Neuendorfstr. 15 A
16761 Hennigsdorf
Tel. +49-3302-20565-0
press@sphingotec.com
www.sphingotec.com
Hennigsdorf, Germany, 23 July 2026 — SphingoTec GmbH announces that its Chief Executive Officer, Deborah Bergmann, will attend the ADLM 2026 Annual Meeting, taking place from July 26 to 30, 2026. During the conference, SphingoTec will engage with current and prospective partners to discuss ongoing collaborations and opportunities to advance innovations in critical care diagnostics. These interactions support SphingoTec’s strategy to expand the clinical and commercial reach of its biomarker portfolio. “ADLM provides an important platform to connect with partners across the diagnostics ecosystem,” said Deborah Bergmann, CEO of SphingoTec. “These discussions align with our commitment to translating biomarker innovation into clinically meaningful solutions for patients in critical care.” About SphingoTec SphingoTec GmbH ("SphingoTec"; Hennigsdorf near Berlin, Germany) is a biomarker company focusing on the out-licensing of innovative critical care solutions for diagnosing, predicting, and monitoring acute medical conditions. SphingoTec develops its biomarkers to the commercial stage and partners with IVD companies to make them available on different IVD platforms. SphingoTec's proprietary biomarker portfolio includes Proenkephalin A 119-159 (penKid), a biomarker for the assessment of kidney function in critical diseases, and bioactive Adrenomedullin 1-52 (bio-ADM), a biomarker for the assessment of endothelial function in conditions like sepsis. Discover more on www.sphingotec.com Media Contact: Email: press@sphingotec.com Phone +49-3302-20565-0 SphingoTec GmbH Neuendorfstr. 15A 16761 Hennigsdorf, Germany
• New ELISA sphingotest® penKid® enables widespread measurement of the kidney function biomarker Proenkephalin 119-159 (penKid) using standard laboratory equipment. • Only available test to match SphingoTec’s reference chemiluminescence assay, developed with patented high-sensitivity technology to provide consistent results across platforms. Hennigsdorf/Berlin, Germany, April 28 2026 - SphingoTec GmbH announces the launch of the ELISA sphingotest® penKid®, a new assay designed to make testing of its proprietary biomarker broadly accessible to research laboratories and pharmaceutical partners. Providing ease-of-use and precision, the test facilitates large-scale investigations of human kidney function in both acute and broader clinical research contexts. Responding to growing research interest The launch follows increasing demand from the scientific community to study penKid - a biomarker reflecting the current state of kidney function in critical care environments. While SphingoTec’s high-sensitivity sphingotest® penKid® assay serves as the reference method for clinical research and third-party IVD assays, the assay technology requiring dedicated equipment was not easily adoptable in research laboratories. The new ELISA sphingotest® penKid® now allows researchers worldwide to benefit from SphingoTec’s patented detection technology using standard photometers, extending penKid testing capability to a wider range of laboratories. Proven performance and data continuity The ELISA sphingotest® penKid® has been developed to achieve excellent correlation with SphingoTec’s reference chemiluminescence assay, ensuring consistent, high-quality results across different assay platforms. Both methods share the same underlying technology capable of detecting penKid concentrations in the picomolar range. Thanks to this technology transfer, researchers can rely on the same analytical precision and reliability that supported the clinical studies establishing penKid as a valuable kidney function biomarker. The assay’s robust design and German manufacturing ensure durable consistency and reproducibility. With this research-use ELISA, SphingoTec responds to the increasing availability of non-validated assays and encourages researchers to not compromise assay quality and performance to ensure trustworthy results - since data from non-validated tests may reflect assay limitations rather than the true performance of the penKid biomarker. Complementary approaches for clinical use and scientific exploration SphingoTec pursues its commercial strategy for the biomarker penKid through strategic out-licensing partnerships such as Boditech Med, which has developed an IVDR-certified assay for routine clinical use and rapid diagnostics. The newly launched ELISA sphingotest® penKid® represents a complementary initiative, specifically designed to support high-throughput clinical and translational research. Through this dual approach, SphingoTec reaffirms its commitment to fostering scientific collaboration and promoting the broader exploration of penKid across diverse research settings. “Developing the ELISA sphingotest® penKid® reflects our long-term commitment to improving critical care diagnostics,” said Deborah Bergmann, Managing Director and CEO of SphingoTec GmbH. “Beyond its currently validated clinical applications, we see strong potential for penKid to support research and improve diagnostics in other fields where kidney function is relevant. By encouraging scientists worldwide to incorporate penKid into their studies and clinical programs, we aim to accelerate innovation and advance best-fit diagnostic solutions that ultimately improve patient care.” About SphingoTec SphingoTec GmbH ("SphingoTec"; Hennigsdorf near Berlin, Germany) is a biomarker company focusing on the out-licensing of innovative critical care solutions for diagnosing, predicting, and monitoring acute medical conditions. SphingoTec develops its biomarkers to the commercial stage and partners with IVD companies to make them available on different IVD platforms. SphingoTec's proprietary biomarker portfolio includes Proenkephalin A 119-159 (penKid), a biomarker for the assessment of kidney function in critical diseases, and bioactive Adrenomedullin 1-52 (bio-ADM), a biomarker for the assessment of endothelial function in conditions like sepsis. Discover more on www.sphingotec.com Media Contact: Email: press@sphingotec.com Phone +49-3302-20565-0 SphingoTec GmbH Neuendorfstr. 15A 16761 Hennigsdorf, Germany